CHELERYTHRINE CHLORIDE

Product Name: CHELERYTHRINE CHLORIDE
CAS No.: 3895-92-9
Chemical Name: CHELERYTHRINE CHLORIDE
Synonyms: 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);CHELERYTHRINE CHLORIDE(RG)
CBNumber: CB3760820
Molecular Formula: C21H18ClNO4
Formula Weight: 383.82
MOL File: 3895-92-9.mol

More

Less

CHELERYTHRINE CHLORIDE Property

Melting point:: 195-205 °C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: ≥10 mg/mL
form: powder
color: yellow to orange
Stability:: Hygroscopic
InChIKey: WEEFNMFMNMASJY-UHFFFAOYSA-M

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-36/37
Safety Statements: 26-36-36/37
RIDADR: UN 1544PSN1 6.1 / PGII
WGK Germany: 3
RTECS: FL9200000
HS Code: 29349990
Toxicity: mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002288
Product name: Chelerythrine chloride
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002288
Price: $152
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2932
Product name: Chelerythrine chloride
Purity: ≥95% (TLC), powder
Packaging: 1mg
Price: $66.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 220285
Product name: Chelerythrine Chloride
Purity: Naturally-occurring alkaloid.
Packaging: 5mg
Price: $187
Updated: 2024/03/01

Alfa Aesar

Product number: J62906
Product name: Chelerythrine chloride, 99+%
Packaging: 5mg
Price: $130.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62906
Product name: Chelerythrine chloride, 99+%
Packaging: 10mg
Price: $200.65
Updated: 2024/03/01

More

Less

CHELERYTHRINE CHLORIDE Chemical Properties,Usage,Production

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC₅₀ = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC₅₀ = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical Properties

yellow to orange solid

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC₅₀ = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.

CHELERYTHRINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CHELERYTHRINE CHLORIDE Suppliers

Australia 1 Belgium 1 China 150 Europe 2 France 2 Germany 8 India 6 Japan 3 Switzerland 2 United Kingdom 13 United States 38 Global 226

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10658
Advantage: 60

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from CHELERYTHRINE CHLORIDE manufacturers

Career Henan Chemical Co

Product: CHELERYTHRINE CHLORIDE 3895-92-9
Price: US $1.00-1.00/kg
Min. Order: 1 mg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

3895-92-9, CHELERYTHRINE CHLORIDERelated Search:

GF109203X GO 6976 D-ERYTHRO-SPHINGOSINE GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE II BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chloromethane Chrysene Chelerythrine 2,3-Dihydroxynaphthalene 8-Isoquinolinol 7-Hydroxyisoquinoline Phenanthridine CHELERYTHRINE CHLORIDE 7,8-BENZOQUINOLINE 7-METHOXY-ISOQUINOLINE 8-Methoxyisoquinoline

TODDALIN

TODDALIN CHLORIDE

3)benzodioxolo(5,6-c)phenanthridinium,1,2-dimethoxy-12-methyl-(chloride

chelerythrinehydrochloride

1,2-DIMETHOXY-12,[1,3]-BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE

1,2-DIMETHOXY-12-METHYL[1,3]BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE

CHELERYTHRIN CHLORIDE

CHELERYTHRIN CL

Chelerythrine cloride

[1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (1:1)

CHELERYTHRINE CHLORIDE(RG)

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

Chelerythrine chloride,98%

Chelerythrine chloride1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Chelerythrine chloride

1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

[1,3]Benzodioxolo[5,6-c]phenanthridiniuM, 1,2-diMethoxy-12-Methyl-, chloride

CHELERYTHRINE CHLORIDE(P)

1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride

Chelerythrine Cl

17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.02,1.0,.01,1]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaen-21-ium chloride

1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride

3895-92-9

16732-75-2

C21H18ClNO4

C12H18NO4

C21H18NO4Cl

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Protein Kinase C (PKC)

Serine/Threonine Kinase Inhibitors

antibiotic

Herb extract

Alkaloids

Protein Kinase